89Zr-PET imaging in humans: a systematic review

Abstract Purpose The remarkable amount of preclinical data achieved on 89 Zr-PET imaging led to a significant clinical translation, concerning mainly immuno-PET applications. aim this systematic review is provide complete overview applications imaging, using approach identify and collect published studies performed in humans, sorted by field application specific disease subsections. Methods A literature search articles suiting the inclusion criteria was conducted Pubmed, Scopus, Central, Web Of Science databases, including papers from January 1967 November 2020. Eligible had be humans through PET with Zr-labeled compounds. methodological quality assessed Quality Assessment Diagnostic accuracy Studies-2 tool. Results total 821 were screened. 74 for eligibility exclusion further 18, thus 56 ultimately selected qualitative analysis. Conclusions Zr has shown powerful PET-imaging tool, particular radiolabeling antibodies order study antigen expression, biodistribution, anticancer treatment planning follow-up. Other than oncologic applications, Zr-radiolabeled have been proposed use inflammatory autoimmune disorders interesting results. nanoparticles represent groundbreaking radiopharmaceuticals potential huge fields application. To evaluate usefulness different conditions real-world settings, widen its practice, translation needed.